Olaniyi, Famobuwa E. and Bamidele, Osho I. and Omokehinde, Akinlami O. and Ayodeji, Agbowuro A. (2015) Anti-inflammatory Activities of the Chloroform Extract of the Fruit of Tetracarpidium conophorum (Mull. Arg.) (Nigerian Walnuts). Journal of Advances in Medical and Pharmaceutical Sciences, 6 (1). pp. 1-7. ISSN 23941111
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Abstract
Objective: To investigate the anti-inflammatory activity of the chloroform extract of the fruit of Tetracarpidium conophorum (CEFTC).
Methods: CEFTC was evaluated for anti-inflammatory activity using standard formalin-induced rat paw edema. The activities of the extract at different doses were compared to diclofenac, a standard anti-inflammatory drug.
Results: In all the experiments, the chloroform extract of T. conophorum at 400 mg/Kg showed anti-inflammatory effects which were significant (p=.05) and comparable to those of diclofenac, whereas CEFTC at 200 mg/Kg was pro-inflammatory. This suggests that the extract could be harmful at low doses.
Conclusion: The results showed that CEFTC at 400 mg/Kg possesses significant anti -inflammatory activity comparable to that of diclofenac, one of the non-steroidal anti-inflammatory drugs (NSAIDS). This supports its use as a potent anti-inflammatory drug in herbal medicine.
Item Type: | Article |
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Subjects: | STM Academic > Medical Science |
Depositing User: | Unnamed user with email support@stmacademic.com |
Date Deposited: | 10 Jul 2023 06:04 |
Last Modified: | 31 Jan 2024 04:39 |
URI: | http://article.researchpromo.com/id/eprint/846 |