Effect of Enzymatic Changes in Vitamin D Combination with LIV-52 on Carbon Tetrachloride Induced Liver Disease in Wistar Rats

Aim: The present study was conducted to investigate the hepatoprotective effect of enzymatic changes in vitamin D combination with Liv-52 on CCl4 induced liver toxicity in Wistar rats.

Background: The central organ of liver plays an essential vital role in the metabolism, and the liver is called as the metabolic “engine-room of the body”. Therefore, to maintain a healthy liver is a crucial factor for overall health and well being. The liver is the central organ for pharmaceutical drug or chemicals and xenobiotic detoxification metabolism, which regulates most of medication and xenobiotic-related toxic activity. High metabolic and synthetic activity in this organ is an important place for the generation of free radicals.

Materials and Methods: Adult male Albino Wistar rats weighing 150-250g were used in this study. The rats were split into six groups, each consisted of six rats. CCl4 were admitted two days in a week for five weeks. Liver disease associated animals were treated with Vitamin D and Liv-52 for 5 weeks.

Results: The levels of AST, ALT, ALP, γ-GT, and AFP were significantly reduced in vitamin D, and Liv-52 treated animals when compared with CCl4 induced animals. Moreover, the levels of Vitamin D and Liv-52, a good indicator of restoring the liver architecture, were also reversed in the damage after treatment.

Conclusion: The results of the present study indicate that the combination drugs were more hepatoprotective effect when compared with the individual.