Haematinic Effects of Aqueous Extract of Lophira lanceolata Leaves in Phenylhydrazine-induced Anaemia in Wistar Rats

Osafanme, Iserhienrhien Lucky and Duniya, Sheneni Victor and Chukwuemeka, Nweje-Anyalowu Paul and Mercy, Oguche and Adejoh, Idakwoji Precious (2019) Haematinic Effects of Aqueous Extract of Lophira lanceolata Leaves in Phenylhydrazine-induced Anaemia in Wistar Rats. Asian Journal of Research in Biochemistry. pp. 1-6. ISSN 2582-0516

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Official URL: https://doi.org/10.9734/ajrb/2019/v4i130057

Abstract

Aim: The haematinic activity of the aqueous extract of Lophira lanceolata leaves was investigated using rat model of phenylhydrazine-induced anaemia.

Methods and Results: Red Blood Cell (RBC) count, Haemoglobin (Hb) concentration and Packed Cell Volume (PCV) were analysed as indices of anaemia. Following phenylhydrazine administration to rats at a dose of 10 mg/kg for 8 days, a significant decrease (P<0.05) in the haematological parameters was observed indicating anaemia. However, treatment with graded doses (200, 400 and 800 mg/kg) of the aqueous extract of Lophira lanceolata leaves produced a significant (P<0.05) increase in the RBC count, Hb concentration and PCV time- and dose- dependently.

Conclusion: It was concluded that Lophira lanceolata leaves possess haematinic activity, making it useful in the management of anaemia.

Item Type:	Article
Subjects:	STM Academic > Biological Science
Depositing User:	Unnamed user with email support@stmacademic.com
Date Deposited:	12 Apr 2023 11:24
Last Modified:	07 May 2024 04:48
URI:	http://article.researchpromo.com/id/eprint/518

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