In silico Drug Docking Interactions between Kaempferol and Apolipoprotein A-I (APOA1)

Apolipoprotein A-I (APOA1) is typically linked to a significant increase in cardiovascular risk and atherosclerosis. Numerous clinico-genetic research have demonstrated this reality. Our work uses 3D Insilico drug docking techniques to make the possible mutant target protein Apolipoprotein A-I (APOA1) interact with kaempferol. One of the main phytochemical components found in Hibiscus rosa-sinensis is kaempferol. It has been demonstrated that Hibiscus rosa-sinensis has a variety of pharmacological actions that can treat a wide range of human illnesses. We investigate the relationship between kaempferol and APOA1. The use of sophisticated 3D molecular visualization tools was employed in post-docking experiments. Kaempferol directly suppresses amino acid mutational sites, as demonstrated by the docking study results. APOA1 and Kaempferol's molecular 3D H-bond interaction is depicted in 3D view-based notions of molecular dynamics techniques. Finally, we draw the conclusion that kaempferol helps to prevent cardiovascular illnesses.