Recent Formulation Development and Evaluation of Lozenges Containing Polyherbal Extract of Cinnamomum tamala and Spilanthes acmella

In recent years, the growing demand for herbal has resulted in a massive increase in the volume of plant material traded within and across the country. Tejpatta (Cinnamomum tamala) and Akarkara (Spilanthes acmella) are two major medicinal plants that are rich in therapeutic constituents. Cinnamomum tamala which is an evergreen tree up to 8 m in height is also cultivated. Spilanthus acmella is an annual hairy herb, up to 40-60 cm. tall with numerous stems of marigold yellow flowers. The goal of this study is to develop a modern dosage form, such as lozenges, that is related with a long-term local cure that has a favourable therapeutic impact. The extracts of Cinnamomum tamala leaves and Spilanthes acmella flowers have antibacterial properties against the selected microorganism (staphylococcus aureus, Streptococcus mutans and Escherichia coli). The existence of various phytochemicals such as alkaloids, flavonoids, glycosides, and triterpenes was confirmed by qualitative phytochemical screening of ethanol, methanol, and petroleum ether extracts of Cinnamomum tamala leaves and Spilanthes acmella flowers extracts. The optimised formula F3 was chosen for the formulation of tablet lozenges and was manufactured by direct compression method, which exhibits optimal friability, weight uniformity, hardness, and disintegration time, according to the results obtained.