Comparison of Effect of Drotavarine Hydrochloride and a Combination of Hyoscine-N-Butyl Bromide & Valethamate Bromide on Duration of Active Phase of Labor

Labor, an important event, is marked by the fear of pain. It is desirable to have a painless and quick labor. The goal of an obstetrician is to deliver a healthy baby and mother. Methods for reducing the active phase of labor are encouraged. Prolonged labour results in a significant rate of feto-maternal morbidity. It is necessary to reduce the duration of labour without risking the feto-maternal interests. Much of the art of good obstetric care involves the delicate balance of avoiding cesarean delivery and its complications. Various strategies were used to try to speed up the labour process. The compounds hyoscine-n-butyl bromide, scopolamine, and valethamate bromide have all been extensively researched. The purpose of this study was to compare the effects of Drotavarine hydrochloride and a combination of Hyoscine-N-butyl bromide and Valethamate bromide on active phase duration and feto-materal side effects. A total of 200 women were separated into two groups of 100 each. Group A received Drotavarine hydrochloride 40mg I/M, 2 doses 2 hours apart(2nd if required). Group B given combination of Hyoscine-N-butyl bromide 40 mg and Valethamate bromide 16mg I/M, 2 doses 2 hours apart(2nd if required). 98% delivered vaginally. 2% (LSCS) in each group and excluded. Mean no. of doses 1.36±0.48 (Group A), 1.83±0.37 (Group B) p value <0.001 HS. Mean rate of dilatation (cms/hr) was more in Group A(3.81±1.52) than B (2.29±0.64) p value<0.001 HS. Mean Active phase was 112.70±53.09 mins in Group A and 171.44±57.24 min in B, p value<0.001 HS. Drug-delivery interval was 45.10±63.22 min (groupA) and 202.09±60.35 min (Group B) p value <0.001HS. There are no significant feto-maternal side effects. Drotavarine and combination drugs are safe to shorten the duration of active phase.