Exploration of the core gene signatures and mechanisms between NAFLD and sarcopenia through transcriptomic level

Xu, Ziying and Yu, Zihui and Li, Shang and Tian, Ziyan and Yuan, Jing and You, Fuping (2023) Exploration of the core gene signatures and mechanisms between NAFLD and sarcopenia through transcriptomic level. Frontiers in Endocrinology, 14. ISSN 1664-2392

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Abstract

Introduction: The increased prevalence of non-alcoholic fatty liver disease (NAFLD) and sarcopenia among the elderly are facing a significant challenge to the world’s health systems. Our study aims to identify the coexpressed genes in NAFLD and sarcopenia patients.

Methods: We downloaded the transcriptome data of NAFLD tissue from patients, as well as muscle tissues from sarcopenia patients, from the GEO database in order to investigate the shared transcriptional regulation mechanisms between these two diseases. Then, focusing on the genes that were frequently expressed in these diseases, together with GSVA and WGCNA, we utilized a range of analysis methods to identify the main co-expressed genes in both diseases by taking intersections. We investigated these changes after learning that they mostly affected lipid metabolism and oxidative stress injury pathways.

Results: By analyzing these genes and their interactions with transcription factors and proteins, we were able to identify 8 genes that share common patterns. From these 8 genes, we were possible to forecast potential future medicines. Our research raises the possibility of NAFLD and sarcopenia transcriptome regulatory pathways in aging populations.

Discussion: In conclusion, a complete transcription pattern mapping was carried out in order to identify the core genes, underlying biological mechanisms, and possible therapeutic targets that regulate aging in NAFLD and sarcopenia patients. It provides novel insights and proof in favor of decreasing the increased prevalence of sarcopenia in the elderly caused by NAFLD.

Item Type: Article
Subjects: STM Academic > Mathematical Science
Depositing User: Unnamed user with email support@stmacademic.com
Date Deposited: 07 Jul 2023 04:38
Last Modified: 12 Oct 2023 07:04
URI: http://article.researchpromo.com/id/eprint/1248

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